Specific Patterns of CD39 Expression on T-cells of HIV/HCV Coinfected Patients Receiving Antiretroviral Therapy: A Case-control Study
Abstract
Human immunodeficiency virus (HIV)/hepatitis C virus (HCV) coinfection leads to severe systemic inflammation, increasing non-AIDS morbidity and mortality risk. CD39 ectoenzyme on T-cells, which catalyzes the conversion of pro-inflammatory purines to immunosuppressive adenosine, plays an important role in inflammation control. The role of CD39+ T-cells in systemic inflammation during HIV/HCV coinfection under antiretroviral therapy (ART) remains unexplored. This study aimed to identify specific patterns of CD39 expression on T-cells in ART-treated HIV/HCV coinfected patients and assess their relationship with systemic inflammation.
Fields of Study & Subjects
Adenosine and Purinergic Signaling
HIV Research and Treatment
HIV-related health complications and treatments
Publication details
- Journal / source
- Gene Expression
- Volume
- 25
- Issue
- 1
- Pages
- e00065–e00065
- Publication date
- 13 January 2026
- Language
- EN