SNCA Variants and Expression Levels of α-synuclein Transcripts in Multiple System Atrophy: A Retrospective Case–control Study
Abstract
Synucleinopathies, including Parkinson’s disease (PD), dementia with Lewy bodies, and multiple system atrophy (MSA), are a group of neurodegenerative diseases characterized by the oligomerization of α-synuclein protein in neurons or glial cells. Various splicing isoforms of α-synuclein have been described, each with different aggregation properties. The α-synuclein gene (SNCA) has been identified as a highly significant genetic risk locus associated with various synucleinopathies across populations. This study aimed to assess the association of SNCA genetic variants with MSA and the levels of SNCA transcripts in peripheral blood mononuclear cells (PBMCs) from MSA and PD patients.
Fields of Study & Subjects
Parkinson's Disease Mechanisms and Treatments
Genetic Neurodegenerative Diseases
Nuclear Receptors and Signaling
Publication details
- Journal / source
- Gene Expression
- Publisher
- Xia & He Publishing
- Volume
- 25
- Issue
- 2
- Pages
- e00091–e00091
- Publication date
- 20 April 2026
- Language
- EN