Computational Insights into the Interactions of Andrographolide Derivative SRJ09 with Histone Deacetylase for the Management of Beta Thalassemia
Abstract
Thalassemia is a group of anemias that result from inherited defects in the production of the beta chain of hemoglobin. It is stabilized by gamma globin, which combines to form fetal hemoglobin. One therapeutic approach is to target histone deacetylase (HDAC), which plays an important role in controlling beta thalassemia. This study sought to identify a natural inducer for treating this disease.
Fields of Study & Subjects
Hemoglobinopathies and Related Disorders
Andrographolide Research and Applications
Computational Drug Discovery Methods
Publication details
- Journal / source
- Journal of Exploratory Research in Pharmacology
- Volume
- 11
- Issue
- 1
- Pages
- e00039–e00039
- Publication date
- 14 January 2026
- Language
- EN