DELIVERY SYSTEM OF BIOLOGICALLY ACTIVE MOLECULES BASED ON DRY LICORICE ROOT EXTRACT GLYCYRRHIZA URALENSIS

The composition of dry licorice root extract obtained from the manufacturer Wisterra by high performance liquid chromatography and gel penetrating chromatography was studied. Mechanochemically, the compositions with a number of poorly soluble biologically active substances - tebuconazole, fenbendazole, betulin, curcumin, melatonin, praziquantel, diosgenin, pinostrobin, albendazole, betulonic acid, vitamin D3 - were obtained and an increase in their solubility and transmembrane permeability was studied. In all cases, a significant up to ~103 -fold increase in these indicators was shown. In this case, the greatest increase in solubility is achieved for less soluble substances. The physico-chemical mechanism of increasing solubility is the incorporation of lipophilic molecules of biologically active substances into supramolecular structures. These structures are micelles and intermolecular complexes which formed by components of licorice extract. Named components are glycyrrhizic acid and poly- and oligosaccharides. An increase in the rate of transmembrane transfer, studied by the RAMPA assay method, has been shown, which should contribute to an increase in the bioavailability of low soluble biology active substances. Thus, the use of licorice extract as an auxiliary substance and mechanochemical technology in the production of nutrients products, including poorly soluble components, is justified in order to enhance their biological effect.