Long-Term Infant Outcomes After In Utero Biologic Exposure: Results From the Pregnancy Inflammatory Disease Neonatal Outcomes Registry
Abstract
INTRODUCTION: Long-term data are needed for offspring exposed in utero to medications for inflammatory bowel disease (IBD). METHODS: We used a prospective cohort of pregnant women with IBD and their offspring (Pregnancy in IBD and Neonatal Outcomes) to compare rates of serious infection, congenital malformations, and developmental delay by medication exposures. RESULTS: We included 438 offspring with at least 4 years of follow-up. No differences in adverse outcomes were observed by medication. Preterm birth, but not specific drug exposure, was associated with infection risk. Breastfeeding was not associated with serious infection differences. DISCUSSION: These findings support the use of effective IBD therapies throughout pregnancy.
Fields of Study & Subjects
Pregnancy and Medication Impact
Pharmacological Effects and Toxicity Studies
Prenatal Substance Exposure Effects
Publication details
- Journal / source
- The American Journal of Gastroenterology
- Volume
- 121
- Issue
- 9
- Pages
- 2343–2347
- Publication date
- 6 March 2026
- Language
- EN