Rapid Induction of Remission With Upadacitinib Followed by Cytomegalovirus Colitis in a Hospitalized Patient With Crohn's Disease

ACG Case Reports Journal 2026 Open access

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Authors: Reid Herran, Samuel Wilcox, Gal Hodish, Asma Nusrat, Jiaqi Shi, Abhishek Satishchandran, Rutwik Pradeep Sharma, Shrinivas Bishu, Syed Adeel Hassan, John Byrn, Andrea Todisco, Haley Mertens
+3 more Anastasia I. Wasylyshyn, Peter D R Higgins, Jeffrey Aaron Berinstein
DOI: 10.14309/crj.0000000000001961
Cited by: 0
References: 6

Abstract

A 60-year-old woman with acute severe Crohn's colitis had a rapid initial response to off-label, high-intensity upadacitinib; however, she subsequently demonstrated clinical deterioration ultimately undergoing colectomy for suspected refractory Crohn's disease. Surgical pathology unexpectedly revealed quiescent Crohn's disease with cytomegalovirus colitis, despite no initial endoscopic evidence of infection.

Fields of Study & Subjects

Cytomegalovirus and herpesvirus research Inflammatory Bowel Disease Diagnosis and treatment of tuberculosis

Publication details

Journal / source
ACG Case Reports Journal
Volume
13
Issue
1
Pages
e01961–e01961
Publication date
1 January 2026
Language
EN