Russell Body Esophagitis Without Associated Barrett's Esophagus

ABSTRACT Russell body esophagitis (RBE) is a rare disease characterized by accumulation of Russell bodies (eosinophilic immunoglobulin inclusions) within plasma cells leading to esophageal inflammation. Fewer than 10 cases have been reported, and most are associated with chronic gastroesophageal reflux disease or Barrett's esophagus. We present a case of RBE in a 36-year-old woman with untreated human immunodeficiency virus at acquired immunodeficiency syndrome stage with esophageal candidiasis. To our knowledge, this represents the second RBE case report not associated with Barrett's esophagus. This report demonstrates the association of RBE with chronic inflammation and immunosuppression and contributes to the sparse literature on this rare condition.