Upadacitinib for the Treatment of Cutaneous Crohn's Disease Presenting as Lymphangioma Circumscriptum

ACG Case Reports Journal 2026 Open access

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Authors: Benjamin Gerstein, William C. Lau, Avi Bitterman, Jonas A. Adalsteinsson, Zoë S. Gottlieb, Rachel Kassenoff, Ahuva D. Cices
DOI: 10.14309/crj.0000000000001983
Cited by: 0
References: 14

Abstract

Metastatic Crohn's disease refers to cutaneous Crohn's disease noncontiguous with the gastrointestinal tract. Vulvar lymphangioma circumscriptum is a rare manifestation of metastatic Crohn's disease, presenting as pink papillomatous or vesicular papules and plaques. Treatment options are limited and often invasive, and clearance is difficult to achieve. We report a novel case of vulvar lymphangioma circumscriptum secondary to Crohn's disease successfully managed with oral and topical Janus kinase inhibitors in combination with procedural therapies.

Fields of Study & Subjects

Autoimmune and Inflammatory Disorders Inflammatory Bowel Disease Vascular Malformations and Hemangiomas

Publication details

Journal / source
ACG Case Reports Journal
Volume
13
Issue
3
Pages
e01983–e01983
Publication date
1 March 2026
Language
EN