Crohn's Disease Complicated by Undiagnosed Hemophilia A: A Case of Recurrent Massive Lower Gastrointestinal Bleeding

ACG Case Reports Journal 2026 Open access

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Authors: Caroline Soares, Miguel Rodrigues, Diana Martins, P C Sousa, Eugénia Cancela, Maria João Ferreira, Carlos Casimiro, Américo Silva, P Ministro
DOI: 10.14309/crj.0000000000002065
Cited by: 2
References: 16

Abstract

Severe gastrointestinal bleeding is a rare but potentially fatal complication of Crohn's disease (CD). In the literature, there are some previously described cases, but there are no clear guidelines on how to manage these patients. We present the case of a patient with ileal CD and previously unknown hemophilia A. The patient experienced 2 episodes of massive intestinal bleeding, the last one requiring surgery. The disease proved difficult to treat with extension to upper gastrointestinal tract, despite being on biological therapy. In addition, diagnosis of coagulation disorders as hemophilia in patients with CD is rare but potentially catastrophic, requiring prepared multidisciplinary teams.

Fields of Study & Subjects

Hemophilia Treatment and Research Platelet Disorders and Treatments Celiac Disease Research and Management

Publication details

Journal / source
ACG Case Reports Journal
Publisher
Ovid Technologies (Wolters Kluwer Health)
Volume
13
Issue
4
Pages
e02065–e02065
Publication date
1 April 2026
Language
EN