Sertraline-Associated Microscopic Colitis Flare in Pregnancy

ACG Case Reports Journal 2026 Open access

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Authors: Alessandra Saraga, Rachel L. Bocchino, Ajay Gade, Michelle Joy Wang, Melissa H. Spiel, Adam S. Cheifetz, Loren G. Rabinowitz
DOI: 10.14309/crj.0000000000002104
Cited by: 1
References: 12

Abstract

Microscopic colitis (MC) is a histologically confirmed cause of chronic diarrhea with normal endoscopy, and limited data complicate diagnosis and management during pregnancy. We report a 31-year-old woman with lymphocytic colitis, initially misdiagnosed as irritable bowel syndrome, who experienced an MC flare at 15 weeks' gestation after starting sertraline. Symptoms resolved with sertraline discontinuation and budesonide, with remission maintained postpartum. This case underscores the importance of medication review, early recognition, and multidisciplinary care in pregnant patients with persistent diarrhea, particularly when coordinating gastrointestinal and psychiatric management.

Fields of Study & Subjects

Microscopic Colitis Inflammatory Bowel Disease Celiac Disease Research and Management

Publication details

Journal / source
ACG Case Reports Journal
Publisher
Ovid Technologies (Wolters Kluwer Health)
Volume
13
Issue
5
Pages
e02104–e02104
Publication date
24 April 2026
Language
EN