Increased Cardiovascular and Cerebrovascular Events in Patients With Lean vs Non-lean MASLD: A Multicenter Analysis

Clinical and Translational Gastroenterology 2026 Open access

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Authors: Omar Al Ta’ani, Yahya Alhalalmeh, Mohammad Alabdallat, Abdallah Naser, Saqr Alsakarneh, Saleh Saleh, Pojsakorn Danpanichkul, Dushyant Dahiya Singh, Basile Njei, Nikki Duong
DOI: 10.14309/ctg.0000000000000974
Cited by: 8
References: 29

Abstract

INTRODUCTION: Metabolic dysfunction-associated steatotic liver disease (MASLD) represents a significant contributor to morbidity and mortality, linked to adverse cardiovascular outcomes. While extensive research highlights the cardiovascular burden in non-lean MASLD, lean MASLD remains comparatively understudied. To address this gap, our study evaluates cardiovascular outcomes in lean MASLD compared with non-lean MASLD. METHODS: This is a retrospective cohort study of patients with MASLD identified in the multi-institutional database, TriNetX. Lean MASLD was defined as a body mass index

Fields of Study & Subjects

Liver Disease Diagnosis and Treatment Liver Disease and Transplantation Diet and metabolism studies

Publication details

Journal / source
Clinical and Translational Gastroenterology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Volume
17
Issue
4
Pages
e00974–e00974
Publication date
30 January 2026
Language
EN