Mean Arterial Pressure at Admission Predicts 28-day Mortality in Patients With Severe Alcohol-Associated Hepatitis

Clinical and Translational Gastroenterology 2026 Open access

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Authors: Meritxell Ventura-Cots, Ana Clemente, Edilmar Alvarado-Tapias, Sujan Ravi, Berta Cuyàs, M Tanguy, Maria Poca, Marion Jäger, Carlos Fernández‐Carrillo, Gavin E. Arteel, Ares Villagrasa, Anna Aguilar-Amorós
+29 more Josepmaria Argemí, Juan G. Abraldes, Francisco Bosques, Robert S. Brown, Guadalupe Garcia-Taso, Juan Genesca, Bernd Schanbl, Phillipe Mathurin, Alexander Louvet, Michael R. Lucey, Debbie L. Shawcross, Elisabeth Verna, Samer Gawrieh, Srinivasan Dasarathy, Wanzhu Tu, Patrick S Kamath, Naga P Chalasani, Craig James McClain, Gyongyi Szabo, Qing Tang, Bruce Barton, Laura E. Nagy, Vijay H Shah, Arun J Sanyal, Mack C. Mitchell, Ashwani K Singal, Germà Soriano, Pierre‐Emmanuel Rautou, Ramon A. Bataller
DOI: 10.14309/ctg.0000000000001053
Cited by: 1
References: 44

Abstract

INTRODUCTION: Alcohol-associated hepatitis (AH) is a severe condition with high short-term mortality. Identifying key predictors of poor outcomes is critical for guiding therapeutic strategies. Mean arterial pressure (MAP), a key determinant of tissue perfusion and systemic hemodynamics, may play a pivotal role in prognosis. METHODS: We analyzed a multicenter, prospective cohort of 323 patients hospitalized with AH, with validation in an independent cohort of 290 patients. Survival was evaluated using Kaplan-Meier curves and compared with the log-rank (Mantel-Cox) test. Cox proportional hazards models were used to estimate hazard ratios for mortality, adjusted for Model for end stage liver disease score. Mechanistic insights were explored through assessment of cardiovascular biomarkers. RESULTS: A baseline MAP

Fields of Study & Subjects

Alcohol Consumption and Health Effects Liver Disease and Transplantation Liver Disease Diagnosis and Treatment

Publication details

Journal / source
Clinical and Translational Gastroenterology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Volume
17
Issue
8
Pages
e01053–e01053
Publication date
3 June 2026
Language
EN