Ultrasound-Assisted Liquid Antisolvent Method Enables Rapid Synthesis of Bioactive Nanocurcumin

Curcumin, a bioactive compound derived from turmeric, has significant pharmacological potential but suffers from poor aqueous solubility (1000 nm to 255 nm (76% reduction), accompanied by a decrease in crystallinity from 58.7% to 21% and a reduction in enthalpy of fusion from 442.61 to 28.57 kJ/mol (93% decrease), indicating partial amorphization. Dissolution was markedly enhanced, achieving 94.36% release within 60 min, compared with only 7.75% for raw curcumin. Antioxidant activity improved significantly, with IC₅₀ values decreasing from 15 mg/mL (without sonication) to