Melkersson–Rosenthal Syndrome: The Role of The Dentist In Early Diagnosis: A Case Report

Melkersson–Rosenthal syndrome (MRS) is a rare disorder that belongs to the group of orofacial granulomatosis. It is classically defined by a clinical triad consisting of recurrent ‎orofacial edema, peripheral facial nerve palsy, and fissured tongue, although the complete ‎form is uncommon. Diagnosis relies mainly on histopathological examination, which demonstrates non-caseating granulomatous inflammation. The etiology and pathophysiology of MRS ‎remain unclear, and current treatments are essentially symptomatic, with variable efficacy ‎and frequent recurrences. Dentists play a crucial role in early diagnosis, as oral manifestations ‎are often the first signs of the disease. This article reports a clinical case and discusses the ‎diagnostic approach and therapeutic management of MRS based on a review of the ‎literature‎.