Hepatoprotective Activities of Seed Extract and Fractions of Telfairia occidentalis on Doxorubicin-Induced Hepatotoxicity in Rats

Biology Medicine & Natural Product Chemistry 2026 Open access

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Authors: Ugochi Queenette Nwosu, Chinyelu Clementina Osigwe, Ugonma Florence Uwaeme, U A Fabian, Jude Efiom Okokon
DOI: 10.14421/biomedich.2025.142.1529-1536
Cited by: 0

Abstract

Telfairia occidentalis Hook (cucurbitaceae) seeds, which is used in the preparation of soups and as medicine traditionally to treat various diseases by the Ibibios was investigated for effect against doxorubicin-induced hepatotoxicity. The seed extract (138 -553 mg/kg) and fractions; dichloromethane (DCM) and aqueous, 276 mg/kg) were evaluated for hepatoprotective activity against doxorubicin-induced liver injury in rats. Liver function parameters, liver oxidative stress markers and liver histology were used to assess the liver protective potential of the extract and fractions. The seed extract and fractions significantly (p

Fields of Study & Subjects

Drug-Induced Hepatotoxicity and Protection Chemotherapy-induced organ toxicity mitigation Chemotherapy-induced cardiotoxicity and mitigation

Publication details

Journal / source
Biology Medicine & Natural Product Chemistry
Volume
14
Issue
2
Pages
1529–1536
Publication date
12 January 2026
Language
EN