Osteofibrous dysplasia (OFD) and adamantinoma: A comprehensive review and updates.

Osteofibrous dysplasia (OFD) and adamantinoma constitute rare bone tumors. Currently, the World Health Organization (WHO) classification of soft tissue and bone tumors stratifies adamantinoma into three main subtypes, namely OFD-like adamantinoma, classic adamantinoma, including its various growth patterns, and an extremely uncommon subtype, dedifferentiated adamantinoma. Given the wide clinicopathological spectrum of adamantinoma, several tumors constitute the differential diagnoses. An exact diagnosis in these scenarios has significant treatment-related implications, such as synovial sarcoma vs. spindle cell-type adamantinoma, and metastatic sarcomatoid carcinoma vs. adamantinoma, to name but a few. There have been studies attempting to explore the proximity/relationship between OFD, OFD-like adamantinoma, and classic adamantinoma. This review focuses on the clinical, radiological, and pathological features of OFD, as well as the histopathological spectrum of adamantinoma, including its updates and various subtypes and tumors that constitute its differential diagnosis.