Empagliflozin protected kidney function in CKD rat through suppressing hypoxic and fibrotic signalings mediated inflammation and EMT.

PubMed 2026 Open access

Read full text
Authors: Chih‐Chao Yang, Jui‐Ning Yeh, Tsuen‐Wei Hsu, John Y. Chiang, Ben-Chung Cheng, Pei‐Hsun Sung, Shun‐Cheng Wu, Chi‐Ruei Huang, Pei‐Lin Shao, Hon-Kan Yip
DOI: 10.14670/hh-18-953
Cited by: 1

Abstract

BACKGROUND: This study tested the hypothesis that PI3K/Akt/GSK3β and TGF-β/Smad2/3 signaling play essential roles in mediating the epithelial-mesenchymal transition (EMT) and fibrosis, resulting in the deterioration of renal function and parenchyma in chronic kidney disease (CKD) rats, which is reversed by early empagliflozin treatment. METHODS AND RESULTS:

Fields of Study & Subjects

Pancreatic function and diabetes Diabetes Treatment and Management Chronic Kidney Disease and Diabetes

Publication details

Journal / source
PubMed
Volume
41
Issue
2
Pages
319–337
Publication date
1 February 2026
Language
EN