Suppressing SMURF1 to preserve GSTM2: An approach to reducing gastric cancer aggressiveness in vitro and in vivo.

PubMed 2026 Open access

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Authors: Guoming Ma, Jingwu Li, Yuanting Lu, Weiwei Zuo
DOI: 10.14670/hh-18-974
Cited by: 0

Abstract

BACKGROUND: Smad Ubiquitination Regulatory Factor-1 (SMURF1) is implicated in promoting gastric cancer progression by enhancing cell proliferation, migration, and invasion. This study aims to elucidate how SMURF1 drives gastric cancer aggressiveness, with a focus on its interaction with Glutathione S-transferase mu 2 (GSTM2). METHODS: tumorigenicity was assessed in a xenograft mouse model, alongside analysis of tumor growth and molecular markers of epithelial-mesenchymal transition (EMT). RESULTS: , GSTM2 overexpression suppressed tumor growth and EMT markers, such as Vimentin, while elevating E-cadherin, which was offset by SMURF1 upregulation. CONCLUSION: .

Fields of Study & Subjects

Glutathione Transferases and Polymorphisms Computational Drug Discovery Methods Enzyme function and inhibition

Publication details

Journal / source
PubMed
Volume
41
Issue
3
Pages
505–516
Publication date
1 March 2026
Language
EN