Daphnetin alleviates renal inflammation, oxidative stress, and apoptosis in septic rats via the JAK2/STAT3 signaling pathway.

PubMed 2026 Open access

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Authors: Zhuo Zhang, Pan Hu, Qingye Li, Yingling Wang, Runchen Yao
DOI: 10.14670/hh-18-978
Cited by: 0

Abstract

experiments showed that DAP or AG490 (a JAK2 inhibitor) alleviated LPS-induced apoptosis, inflammation, and oxidative stress. In conclusion, DAP attenuates sepsis-induced AKI by reducing inflammation, oxidative stress, and apoptosis via the inactivation of the JAK2/STAT3 pathway.

Fields of Study & Subjects

Pharmacological Effects of Natural Compounds Tryptophan and brain disorders Medicinal Plants and Bioactive Compounds

Publication details

Journal / source
PubMed
Volume
41
Issue
4
Pages
651–660
Publication date
1 April 2026
Language
EN