UCHL1 enhances TSC1 transcription by stabilizing FOXO1 through deubiquitination in knee osteoarthritis.

PubMed 2026 Open access

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Authors: Yu Wang, Jiawei Lu, Chonghao Gu, Zikang Xie, Zhongyu Xia, Bingqing Guo, Tao Jiang
DOI: 10.14670/hh-18-995
Cited by: 0

Abstract

experiments demonstrated that UCHL1 alleviated cartilage damage in KOA rats by inhibiting ferroptosis and ECM degradation through the FOXO1/TSC1 axis. These findings demonstrate the pivotal role of UCHL1 in regulating ferroptosis and maintaining ECM homeostasis, offering novel insights into the molecular mechanisms driving KOA progression.

Fields of Study & Subjects

NF-κB Signaling Pathways Ubiquitin and proteasome pathways Peptidase Inhibition and Analysis

Publication details

Journal / source
PubMed
Volume
41
Issue
5
Pages
863–878
Publication date
1 May 2026
Language
EN