PIP5K3 upregulation correlates with unfavorable prognosis in patients with nasopharyngeal carcinoma.

PubMed 2026 Open access

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Authors: Shuna Yao, Hung‐Chang Wu, Ching‐Chieh Yang, Yun-Tzu Lin, Chien‐Feng Li, Shih‐Lun Chang, Yu‐Hsuan Kuo
DOI: 10.14670/hh-18-996
Cited by: 0

Abstract

BACKGROUND: Nasopharyngeal carcinoma (NPC) is prevalent in East and Southeast Asia, with metastasis and recurrence leading to poor prognosis. Identifying prognostic biomarkers is essential. METHODS: We analyzed differentially expressed genes involved in the phosphatidylinositol metabolic process (GO: 0046488) and tumorigenesis (GSE12452) in NPC. Associations between PIP5K3 expression and clinicopathological features were assessed using chi-square tests and Cox proportional hazards models. RESULTS:

Fields of Study & Subjects

Cancer-related Molecular Pathways PI3K/AKT/mTOR signaling in cancer Protein Kinase Regulation and GTPase Signaling

Publication details

Journal / source
PubMed
Volume
41
Issue
5
Pages
879–887
Publication date
1 May 2026
Language
EN