Regulation of G Protein Signaling 14 protects against cerebral ischemic reperfusion injury by inhibiting the TAK1-JNK/p38 signaling pathway.

PubMed 2026

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Authors: Gang Zhou, Changquan Wang, Wenyi Bai, Ju Gao, Yugao Liao, Lei Wang, Xiangbo Wu, Yu Tian, Guanglin Wang, Guangming Xia, Jinhua Wang
DOI: 10.14670/hh-25-018
Cited by: 0

Abstract

BACKGROUND: Stroke is a crucial cause of morbidity and mortality worldwide. The regulator of G protein signaling 14 (RGS14) plays important roles in mediating multiple signaling pathways and various pathophysiological processes. However, the function of RGS14 in cerebral ischemic reperfusion injury (CIRI) remains unknown. METHODS AND RESULTS: -infected primary neurons. CONCLUSIONS: These findings imply that RGS14 is a novel negative regulator and may serve as a potential therapeutic target for CIRI.

Fields of Study & Subjects

NF-κB Signaling Pathways Neuroinflammation and Neurodegeneration Mechanisms Melanoma and MAPK Pathways

Publication details

Journal / source
PubMed
Volume
41
Issue
9
Pages
1527–1540
Publication date
1 September 2026
Language
EN