Club (Clara) cells in human prostate: A survival guide for conventional histologists/histopathologists.
Abstract
). This review provides a comprehensive synthesis of current knowledge regarding prostatic Cc and Cc-phenotype conversion across prostate disease. Prostatic Cc possesses anti-inflammatory, regenerative, and immunoregulatory potential, and exhibits features like those of their pulmonary counterparts. Their ontogenesis, localization across different prostatic zones, gene expression profile, and histo-functional morphology are discussed and illustrated immunohistochemically using original material from the authors. Pathophysiological and morphogenetic considerations are also presented.
Fields of Study & Subjects
Prostate Cancer Treatment and Research
Urologic and reproductive health conditions
Prostate Cancer Diagnosis and Treatment
Publication details
- Journal / source
- PubMed
- Volume
- 41
- Issue
- 7
- Pages
- 1145–1152
- Publication date
- 1 July 2026
- Language
- EN