AHNAK2 is a novel diagnostic biomarker for gallbladder adenocarcinoma.

PubMed 2026

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Authors: Lingli Chen, Qi Song, Lei Xu, Xinyi Zhang, Minying Deng, Jun Huang, Jieakesu Su, Huimei Wang, YY Hou
DOI: 10.14670/hh-25-032
Cited by: 0

Abstract

OBJECTIVE: To investigate the pathological diagnostic value of AHNAK2 in gallbladder carcinoma (GBC), especially in adenocarcinoma (AC). METHODS: Tissue microarrays (TMAs) were constructed from 296 gallbladder tumor cases, comprising 562 cores that included normal/atypical epithelium, low-grade intraepithelial neoplasia (LGIN), high-grade intraepithelial neoplasia/carcinoma in situ (HGIN/TIS), and GBC. Immunohistochemical staining for AHNAK2 and IMP3 was performed on these TMAs and another 10 GBC cases, and the sensitivity and specificity of AHNAK2 were assessed across different gallbladder tumor types. RESULTS:

Fields of Study & Subjects

Cholangiocarcinoma and Gallbladder Cancer Studies Gallbladder and Bile Duct Disorders Pediatric Hepatobiliary Diseases and Treatments

Publication details

Journal / source
PubMed
Volume
41
Issue
7
Pages
1289–1298
Publication date
1 July 2026
Language
EN