The Effect of Magnesium Infusion in Postoperative Analgesia in Coronary Artery Bypass Graft Surgery

Objectives: It has been shown that patients who have undergone noncardiac surgery experience decreased postoperative pain when given magnesium sulfate (MgSO₄).In this study, we aimed to investigate the effects of MgSO₄ infusion on postoperative pain in coronary artery bypass graft (CABG) surgery.Methods: After approval from the Ethics Committee and obtaining informed consent, 100 patients undergoing elective CABG, classified as ASA-III and having a preoperative EF above 40%, were selected.The patients were prospectively randomized to group I (n=50), which received MgSO₄ (15 mg -1 kg -1 h -1 ), and group II (control) (n=50).Both groups received morphine infusion (0.07 mg -1 kg -1 h -1 ) postoperatively via PCA.To evaluate analgesia, pain scores were assessed using VAS immediately after extubation and at 2, 6, and 12 hours.Simultaneously, the number of requests made to the PCA device, the number of requests met, and the total morphine dose were determined and recorded.In the statistical analysis (SPSS), differences between groups were evaluated using Student's t test and two-way analysis of variance (p