Development of Method to Increase Energy Consumption to Improve Obesity Type 2 Diabetes

Obesity, often linked to high-fat (HF) diets and sedentary lifestyles, exacerbates metabolic syndrome and diabetes, significantly heightening risks for cerebrocardiovascular disease and cancer. Decreased plasma adiponectin (Ad) levels in obesity contribute to insulin resistance and diabetes. Importantly, J-DOIT3 showed that the average HDL cholesterol level was significantly higher in the intensive-therapy group compared to the conventional-therapy group, likely due to increased physical activity. This could independently protect against risk factors. Therefore, targeting AdipoRs emerged as a promising therapeutic strategy. Activation of AdipoRs, akin to caloric restriction and exercise, shows potential not only to alleviate non-communicable diseases but also to extend lifespan in HF diet-induced obesity.