Serum GPNMB as a Surrogate Marker of Aging

Juntendō Igaku/Juntendo igaku 2026 Open access

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Authors: Chieh-Lun Hsiao, Goro Katsuumi, Yohko Yoshida, MAYUMI KOBAYASHI, Jiaqi Liang, Saori Kakehi, Hiroki Tabata, YOSHIHUMI TAMURA, Tohru Minamino
DOI: 10.14789/ejmj.jmj26-0014-s
Cited by: 0

Abstract

Background Recently, we identified GPNMB as a marker of cellular senescence and developed a vaccine to eliminate senescent cells targeting GPNMB. However, the relationship between blood levels of this protein and individual aging has not been clarified. In the light of evidence that GPNMB is associated with individual aging both in mouse and human tissues through various omics studies, we conducted the study to test whether GPNMB level in the blood is also associated with aging and becomes a surrogate marker of aging.

Fields of Study & Subjects

Telomeres Telomerase and Senescence Genetics Aging and Longevity in Model Organisms Aging and Gerontology Research

Publication details

Journal / source
Juntendō Igaku/Juntendo igaku
Volume
72
Issue
Suppl_1
Pages
18–18
Publication date
1 January 2026
Language
EN