Effect of Stress and Daily Exercise on the Expression of Signal Transducer and Activator of Transcription 3 (STAT3) in the Rats Amygdala
Abstract
Aims Chronic stress dramatically increases blood pressure (BP) whereas exercise habits inhibit this reaction in rats. Besides, the amygdala plays an important role in emotional processing, stress responses, and BP regulation. In our preceding study, chronically stressed rats significantly increased their BP compared with those in the control group and voluntary exercise led to a significant reduction in elevated BP levels. In addition, the signal transducer and activator of transcription 3 (STAT3) gene expressions on the amygdala seem to be involved in these responses. In this study, in order to confirm those findings, we focused on the STAT3 protein expression in rats’ amygdala under chronic stress-induced high BP and daily exercise conditions.
Fields of Study & Subjects
Stress Responses and Cortisol
Blood Pressure and Hypertension Studies
Cytokine Signaling Pathways and Interactions
Publication details
- Journal / source
- Juntendō Igaku/Juntendo igaku
- Volume
- 72
- Issue
- Suppl_1
- Pages
- 19–19
- Publication date
- 1 January 2026
- Language
- EN