Myokine R-Spondin 3 Enhances Muscle Tissue Fatigue Resistance and Insulin Sensitivity by Generating Type I Fibers
Abstract
Skeletal muscle constituting about 40% of body weight, plays a crucial role in exercise performance and whole body metabolism. Skeletal muscle tissue is composed of bundles of skeletal muscle fibers that are broadly classified as slow-twitch (type I) and fast-twitch (type II) fibers. Type I fibers are characterized by high contraction endurance and glucose uptake ability compared to type II fibers. Type I fibers undergo relatively less atrophy during age-related muscle atrophy in contrast to type II fibers. indicating that type I fibers exhibit resistance to age-related muscle atrophy. We speculate type I fiber specific molecules play a crucial role in preserving these fibers during atrophy.
Fields of Study & Subjects
Muscle Physiology and Disorders
Adipose Tissue and Metabolism
Exercise and Physiological Responses
Publication details
- Journal / source
- Juntendō Igaku/Juntendo igaku
- Volume
- 72
- Issue
- Suppl_1
- Pages
- 25–25
- Publication date
- 1 January 2026
- Language
- EN