Sex-Specific Impact of GCKR rs1260326 Polymorphism on Metabolic Traits in an older Japanese population: the Bunkyo Health Study

Juntendō Igaku/Juntendo igaku 2026 Open access

Read full text
Authors: Shota Sakamoto, Saori Kakehi, Abulaiti Abudurezake, Hideyoshi Kaga, Yuki Someya, Hiroki Tabata, Yasuyo Yoshizawa, Hitoshi Naito, Tsubasa Tajima, NAOAKI ITO, Ryuzo Kawamori, Hirotaka Watada
+1 more YOSHIFUMI TAMURA
DOI: 10.14789/ejmj.jmj26-0061-s
Cited by: 0

Abstract

Background The T allele of the glucokinase regulatory protein (GCKR) rs1260326 polymorphism (Leu446) is associated with metabolic traits, but has not been reported in older Japanese adults. The prevalence of metabolic disease in Japan shows a large sex-specific difference. This study examines how the rs1260326 polymorphism in the GCKR gene affects metabolic parameters of older Japanese adults in each gender.

Fields of Study & Subjects

Genetic Associations and Epidemiology Diabetes Cardiovascular Risks and Lipoproteins Nutrition Genetics and Disease

Publication details

Journal / source
Juntendō Igaku/Juntendo igaku
Volume
72
Issue
Suppl_1
Pages
66–66
Publication date
1 January 2026
Language
EN