Association Between Statin Use and Mortality in Adults With Parkinson’s Disease: A Nationwide Cohort Study

OBJECTIVE: The impact of statin use on the progression and survival of patients with Parkinson's disease (PD) remains unclear. Moreover, evidence in Asian populations is limited. This study aimed to assess the associations between statin prescription, cumulative dosage, and all-cause mortality in PD patients. METHODS: This retrospective cohort study was conducted using sample data obtained from the Korean National Health Insurance Service (KNHIS) claims database. The study included 3,152 adults who were diagnosed with PD and whose history of statin use and cumulative dose information were obtained from claims records. Data were collected from the KNHIS database, and all eligible participants were followed longitudinally to determine all-cause mortality. The primary outcome was all-cause mortality, and the exposures were statin use (yes or no) and cumulative dose. The analysis was conducted using Cox proportional hazards regression adjusted for relevant covariates. RESULTS: Statin use was associated with a lower risk of all-cause mortality (hazard ratio [HR], 0.600; 95% confidence interval [CI], 0.521-0.691). Among statin users, a higher cumulative statin dose was linked to a further reduction in mortality (HR, 0.800; 95% CI, 0.761-0.842). CONCLUSION: Statin use and increased cumulative exposure were associated with reduced all-cause mortality in patients with PD, and these findings suggest a potential survival benefit and warrant further investigation in diverse populations.