Interplay between uromodulin excretion and water balance in the general adult population
Abstract
Abstract Uromodulin is a kidney‐specific protein that is excreted in the normal urine. Factors regulating its excretion are unknown. Conflicting studies suggest that water balance may influence uromodulin excretion which, in turn, may cooperate with vasopressin to increase water reabsorption in the distal nephron. We analyzed the interplay between uromodulin excretion and water balance in a healthy adult population. Participants were recruited in a population‐based study in Switzerland. The urine uromodulin excretion rate (UUER) (mg/24 h) was measured (ELISA) in parallel with urine osmolality and serum copeptin (pmol/L) (immune‐luminometric assay) as a surrogate for vasopressin. Mixed multi‐variate linear regression models were used. We included 937 participants with 497 (53.0%) women, median age 47.7 years (32.4–61.6) and 27 (2.8%) with eGFR
Fields of Study & Subjects
Ion Transport and Channel Regulation
Electrolyte and hormonal disorders
Sodium Intake and Health
Publication details
- Journal / source
- Physiological Reports
- Publisher
- Wiley
- Volume
- 14
- Issue
- 7
- Pages
- e70844–e70844
- Publication date
- 29 March 2026
- Language
- EN