Characterising of dengue virus’ (DENV’s) host interactions leading to dengue-induced microvascular leakage

University of Surrey Open Research repository 2026 Thesis Open access

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Authors: Justin Duruanyanwu
DOI: 10.15126/thesis.901991
Cited by: 0

Abstract

Approximately 50% of the world is at risk of dengue virus (DENV) infection, which is characterised by prominent vascular leakage in severe cases. This is initiated through microvascular permeability. Previous work showed DENV-2 Non-structural protein-1 (NS1) to disrupt endothelial-pericyte interactions to increase microvascular permeability, utilising human umbilical vein endothelial cells (HUVECs) and saphenous venous pericytes (SVPs) co-cultures.

Fields of Study & Subjects

Mosquito-borne diseases and control Barrier Structure and Function Studies Viral Infections and Vectors

Publication details

Journal / source
University of Surrey Open Research repository
Publication date
27 February 2026
Language
EN
Document type
Thesis