Comparison of blood sample quality and test results between robotic and manual venipuncture: a pilot study

Abstract Objectives This study aimed to evaluate the feasibility of robotic venipuncture in clinical settings and compare its performance with manual venipuncture in terms of blood specimen quality and test results. Methods From March to April 2025, 63 participants (35 females, 28 males), aged 23–73 years, were recruited at Zoucheng People’s Hospital Medical Laboratory Center. Blood samples were collected using both robotic venipuncture and manual venipuncture on April 8, 2025. Specimen quality was assessed pre-testing, and coagulation/biochemical parameters were analyzed. Results Robotic venipuncture demonstrated advantages in reducing venipuncture pain and achieving more consistent blood sample mixing. Compared with manual venipuncture, the robotic system enables more precise control of blood collection volume and anticoagulant ratio. Statistically significant differences (p