Efficacy, adherence, and cost-efficiency of three growth hormone treatment strategies in children with idiopathic short stature: a retrospective cohort study
Abstract
OBJECTIVES: The study compares the efficacy, adherence, and cost-effectiveness of three recombinant human growth hormone (rhGH) regimens in children with idiopathic short stature (ISS) to optimize treatments. METHODS: This retrospective cohort study involved 105 children with ISS who were divided into three groups: short-acting rhGH for 48 weeks (Group 1), PEG-rhGH for 48 weeks (Group 2), and sequential therapy (PEG-rhGH for 24 weeks + short-acting rhGH for 24 weeks) (Group 3). The primary endpoints were the annual changes in the height standard deviation score (ΔHtSDS) and height velocity (HV). Adherence was measured by the missed injection rate (%), and the cost-effectiveness analysis employed the cost-effectiveness ratio. RESULTS: After one year, all regimens improved HtSDS and HV (p
Fields of Study & Subjects
Growth Hormone and Insulin-like Growth Factors
Pituitary Gland Disorders and Treatments
Hypothalamic control of reproductive hormones
Publication details
- Journal / source
- Journal of Pediatric Endocrinology and Metabolism
- Publisher
- Walter de Gruyter GmbH
- Volume
- 39
- Issue
- 3
- Pages
- 236–243
- Publication date
- 27 January 2026
- Language
- EN