Age and sexual maturation at Spermarche in boys with Laron syndrome
Abstract
OBJECTIVES: To determine the age at Spermarche in boys with Laron syndrome (LS), a model of genetic IGF-I deficiency. METHODS: Eight boys with LS and 70 healthy boys with familial short stature followed since early childhood reported the age at their first ejaculation (Spermarche) during examination of the pubertal stage. RESULTS: Spermarche in untreated boys with LS occurred at a mean chronological age of 19.1 ± 2.1 years compared to 14.3 ± 0.4 years in the healthy boys (p=0.002), but their bone ages were similar: 14.8 ± 1.3 vs. 13.5 ± 0.5 y (p=NS). The testicular volume at Spermarche in the untreated boys with LS was: 5.7 ± 1.3 mL compared to 10.0 ± 4.0 mL in the healthy boys (p
Fields of Study & Subjects
Growth Hormone and Insulin-like Growth Factors
Hypothalamic control of reproductive hormones
dental development and anomalies
Publication details
- Journal / source
- Journal of Pediatric Endocrinology and Metabolism
- Publisher
- Walter de Gruyter GmbH
- Volume
- 39
- Issue
- 6
- Pages
- 591–593
- Publication date
- 28 April 2026
- Language
- EN