Reproducibility of the Amsterdam consensus criteria for maternal vascular malperfusion (MVM): a multicenter evaluation of perinatal pathologists

Journal of Perinatal Medicine 2026 Open access

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Authors: Maria Linda Rocha, Thomas Menter, Sandra Zekić Tomaš, Barbara Ciolka, Eumenia Castro, H Coelho, H.M. Keir, Bettina Neumayer, Rosete Nogueira, Maria ­Orsaria, Martyna Trzeszcz, Jo-Anne Ewald
+2 more Carmen A H Severens-Rijvers, G Turowski
DOI: 10.1515/jpm-2025-0518
Cited by: 3
References: 14

Abstract

OBJECTIVES: Maternal vascular malperfusion (MVM) refers to dysfunctional uteroplacental circulation and is associated with increased risk of adverse maternal and fetal outcomes. The diagnosis of MVM is one of the most common pathological diagnoses in term placentas. The aim of the study was to test the interrater reliability of the MVM Amsterdam criteria. METHODS: A group of 12 international perinatal pathologists reviewed digital histological sections of placentas (n=29; 20 MVM/ 9 non-MVM controls), applying published Amsterdam workshop consensus criteria. Kappa statistics were used for interobserver agreement analysis. RESULTS: Agreement levels on final MVM diagnosis according to Amsterdam consensus were calculated as slight to fair (K-values of 0.187 and 0.260, p

Fields of Study & Subjects

Pregnancy and preeclampsia studies Maternal and fetal healthcare Neonatal and fetal brain pathology

Publication details

Journal / source
Journal of Perinatal Medicine
Publisher
Walter de Gruyter GmbH
Volume
54
Issue
4
Pages
811–815
Publication date
2 February 2026
Language
EN