Antenatal corticosteroid prophylaxis in women with increased sFlt-1/PlGF ratio in the clinical routine – A retrospective analysis
Abstract
OBJECTIVES: The sFlt-1/PlGF ratio is a predictive biomarker for preeclampsia (PE)-related outcomes. In women with signs of PE at ≤34 weeks, it may guide the timing of antenatal corticosteroid (ACS) administration. METHODS: We retrospectively analyzed 702 women presenting with signs of PE and/or fetal growth restriction (FGR) between 22+0- and 33+6-weeks. High risk was defined as an sFlt-1/PlGF ratio ≥85. The predictive accuracy of the ratio for PE-related preterm birth at ≤34+0 weeks was assessed using receiver operating characteristic (ROC) analysis. Differences in remaining pregnancy duration and gestational age at delivery between risk groups were analyzed using the log-rank test (p
Fields of Study & Subjects
Pregnancy and preeclampsia studies
Prenatal Screening and Diagnostics
Systemic Lupus Erythematosus Research
Publication details
- Journal / source
- Journal of Perinatal Medicine
- Publisher
- Walter de Gruyter GmbH
- Volume
- 54
- Issue
- 3
- Pages
- 533–542
- Publication date
- 14 January 2026
- Language
- EN