Genetic testing in chronic kidney disease of uneXplained cause (CKDx): clinical insights and evolving diagnostic paradigms
Abstract
Chronic kidney disease (CKD) represents a significant global health burden, with diverse etiologies and often complex clinical presentations. Among these, a notable subset of CKD patients present without a clear underlying cause despite extensive diagnostic evaluation. For this subgroup, the term CKDx - chronic kidney disease of unexplained cause, has recently been proposed. A major element of the diagnostic workup of CKDx is genetic testing, for which the methodology has greatly improved in the last years.
Fields of Study & Subjects
Renal Diseases and Glomerulopathies
Chronic Kidney Disease and Diabetes
Genetic and Kidney Cyst Diseases
Publication details
- Journal / source
- Medizinische Genetik
- Volume
- 38
- Issue
- 1
- Pages
- 21–28
- Publication date
- 3 February 2026
- Language
- EN