Structural studies of a metabotropic glutamate receptor complex
Abstract
Metabotropic glutamate receptor 5 is an excitatory Gq-coupled G protein-coupled receptor predominantly expressed on the postsynaptic sites of neurons. In this study, we want to determine the high resolution structure of mGlu5, a class C GPCR, bound to a positive allosteric modulator and orthosteric agonist quisqualate.
Fields of Study & Subjects
Receptor Mechanisms and Signaling
Neuroscience and Neuropharmacology Research
Enzyme Structure and Function
Publication details
- Journal / source
- European Synchrotron Radiation Facility
- Publication date
- 27 February 2026
- Language
- EN
- Document type
- Dataset