Major adverse cardiac events in patients with amiodarone-induced thyrotoxicosis undergoing thyroidectomy: a multicenter study

European Thyroid Journal 2026 Open access

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Authors: Samuel Frey, Christelle Volteau, Hélène Lasolle, Cecile Caillard, Delphine Drui, S. Pattier, Françoise Borson-Chazot, L. Maillard, Jean‐Christophe Lifante, Eric Mirallié
DOI: 10.1530/etj-25-0292
Cited by: 1
References: 29

Abstract

Objective: Amiodarone-induced thyrotoxicosis (AIT) affects 5-10% of patients on amiodarone therapy, increasing cardiovascular (CV) risk. Total thyroidectomy is proposed for refractory cases, but its long-term impact on major adverse cardiovascular events (MACEs) remains uncertain. This study evaluates post-operative MACEs and cardiac mortality in AIT patients with and without pre-operative left ventricular ejection fraction (LVEF) impairment. Methods: Patients undergoing total thyroidectomy for AIT from 2010 to 2023 in two French referral centers were retrospectively included. They were divided into two groups based on pre-operative LVEF (

Fields of Study & Subjects

Thyroid and Parathyroid Surgery Thyroid Disorders and Treatments Thyroid Cancer Diagnosis and Treatment

Publication details

Journal / source
European Thyroid Journal
Publisher
Bioscientifica
Volume
15
Issue
2
Publication date
27 March 2026
Language
EN