Insulinoma with postprandial hypoglycemia and characteristic expression of GLUT2/GCK/GLP-1R

Journal of Endocrinology 2026

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Authors: Shinichiro Toyoda, Sho Yoneda, Kosuke Mukai, Yoshiya Hosokawa, Yosuke Okuno, Kazuyuki Miyashita, Junji Kozawa, Hitoshi Nishizawa, M Otsuki, Iichiro Shimomura
DOI: 10.1530/joe-25-0134
Cited by: 0

Abstract

Hypoglycemia is the most popular symptom of insulinoma patients. There have been no reports investigating immunohistochemical differences in the expression levels of glucose transporters, glucokinase, and glucagon-like peptide-1 receptor in insulinoma cells according to the clinical phenotypes of hypoglycemia, in particular hypoglycemia in the postprandial state alone or in both fasting and postprandial states. We immunohistochemically analyzed the expression of glucose transporters 1-3, glucokinase, and glucagon-like peptide-1 receptor in insulinoma cells of the resected pancreas from six patients. The frequency of hypoglycemia of

Fields of Study & Subjects

Pancreatic function and diabetes Neuroendocrine Tumor Research Advances Diabetes Management and Research

Publication details

Journal / source
Journal of Endocrinology
Volume
268
Issue
3
Publication date
16 February 2026
Language
EN