Síndrome antisintetasa en un varón residente en una ciudad de gran altitud
Abstract
Antisynthetase syndrome is a rare autoimmune disease which includes polyarthritis, myositis, Raynaud's phenomenon, mechanic's hands, interstitial lung disease and positive anti JO-1 antibody. We report a 44-yearold male patient from Puno, a high-altitude city, who presented with polyarthritis, dyspnea, muscle weakness, edema, and pain in the left lower limb. The patient had positive Anti JO-1, anti SS-A and anti B2 glycoprotein-1 IgG antibodies. A muscle biopsy reported myositis and he was treated with methylprednisolone and cyclophosphamide, with favorable results. Antisynthetase syndrome is a rare disease that slightly predominates in women. The possible role of hypobaric hypoxia in the development of this autoimmune disease is highlighted.
Fields of Study & Subjects
Inflammatory Myopathies and Dermatomyositis
Myasthenia Gravis and Thymoma
Vasculitis and related conditions
Publication details
- Journal / source
- Anales de la Facultad de Medicina
- Volume
- 87
- Issue
- 1
- Pages
- 90–94
- Publication date
- 30 January 2026
- Language
- EN