SARS-CoV-2 Vaccination Before and During Pregnancy and Prevention of Infant COVID-19 Infection

PEDIATRICS 2026 Open access

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Authors: Karen B. Jacobson, Maqdooda A. Merchant, Bruce Fireman, Nicola P. Klein, Ousseny Zerbo
DOI: 10.1542/peds.2025-073000
Cited by: 1
References: 30

Abstract

BACKGROUND: SARS-CoV-2 vaccination during pregnancy reduces COVID-19 risk in infancy. Whether maternal vaccination before pregnancy similarly protects infants against COVID-19 is unknown. METHODS: We examined the effectiveness of maternal messenger RNA SARS-CoV-2 vaccination before and during pregnancy in preventing COVID-19 in infants aged 0-6 months born between July 1, 2021, and June 30, 2023, at Kaiser Permanente Northern California. Maternal vaccination status was categorized as vaccinated during pregnancy, during a prepregnancy interval (0-

Fields of Study & Subjects

COVID-19 Impact on Reproduction Vaccine Coverage and Hesitancy SARS-CoV-2 and COVID-19 Research

Publication details

Journal / source
PEDIATRICS
Publisher
American Academy of Pediatrics (AAP)
Volume
157
Issue
5
Publication date
22 April 2026
Language
EN