A sebgyógyulási fázisok folyamatait befolyásoló antioxidáns és antiinflammatorikus topikális kezelések hatásai és összehasonlító elemzésük

Reactive oxygen species, including oxygen-derived free radicals, play a key roles in all four phases of wound healing. During hemostasis, they participate in platelet activation, and simultaneously with the injury, their prompt release via NOX enzymes from the damaged cell membranes activates polymorphonuclear leukocytes. This continues during the inflammatory phase and also triggers the differentiation of monocytes into macrophages. During the granulation-proliferation process, they induce angiogenesis, and then in the maturation-remodeling phase, they are active in regulating endoproteases and maintaining collagen balance. Their excessive production can cause cell damage, prolonged inflammation, and disorders in chronic wound healing. Topical (local) and systemic antioxidant or anti-inflammatory therapies used at any stage of wound treatment play a crucial role in promoting wound healing, minimizing scar formation, and enhancing patient comfort. The effectiveness of various local therapies, such as silicone-based gel preparations, herbal creams, hyaluronic acid gels, and products derived from regenerative medicine, has been the subject of numerous international studies. This study aimed to evaluate the clinical effects of the most commonly used treatments and active ingredients - e.g., H2O2, povidone-iodine, vitamins C and E, alkaloids, polyphenols (flavonoids), phytomodulators, N-acetylcysteine, honey, silver, etc. - with particular regard to wound healing time, frequency of inflammatory reactions and the aesthetic appearance of scars. Based on a systematic review of international literature, it can be concluded that during the hemostasis phase of wound healing, the presence of low concentrations of endogenous hydrogen peroxide or the diluted form of the exogenous solution, while preparations containing natural antioxidants, have anti-inflammatory and skin-nourishing effects during the inflammation-proliferation phase. During the late phase of wound healing, specifically the maturation-remodeling phase, silicone-based treatments consistently show better results in reducing scarring. The analysis highlights that the personalized use of antioxidant and anti-inflammatory topical active ingredient therapies tailored to the specific phases of wound healing is key to achieving optimal postoperative results following surgery. Orv Hetil. 2026; 167(3): 109-118.