Circadian rhythms and asthma: exploring the impact of circadian clock proteins on childhood asthma management

BACKGROUND: Asthma is a chronic inflammatory disorder characterized by airway inflammation and hyperresponsiveness, significantly impacting children's quality of life. Despite optimal treatment, some children experience poor asthma control, partly attributed to circadian rhythm disturbances. OBJECTIVES: This study aimed to evaluate circadian clock protein levels and their relationship with asthma control and sleep quality in children. METHODS: Patients with asthma aged 8-17 years and age-matched healthy controls were enrolled. Pulmonary function was assessed using spirometry, asthma control via the Asthma Control Test (ACT), and sleep quality using the Children's Sleep Habits Questionnaire (CSHQ). Serum circadian protein levels (BMAL1, CLOCK, CRY1, CRY2, PER1, and PER2) were quantified and compared between groups. RESULTS: Asthmatic children had significantly elevated levels of BMAL1, CLOCK, CRY1, PER1, and PER2 compared to controls (p