Cutaneous Mastocytosis in an Infant: Case Study

Background . Cutaneous mastocytosis in children is a rare disease with benign outcome in most cases, however, its course can be aggravated by transformation into mast cell leukemia at the age over 10 years. Moreover, interpreting disease skin syndromes can be challenging in infants. Case description. Case of generalized cutaneous mastocytosis in an infant with regression of the clinical picture by the age of 11 months is described. Disease onset was at 2 months: rashes appeared in the body folds. The patient was diagnosed with Darier – Unna sign upon clinical examination. Laboratory examination has revealed increased total serum tryptase up to 17 μg/l, total IgE — up to 116 IU/ml. There were positive changes (skin syndrome relief, decrease in rashes severity) on treatment with second-generation antihistamine at an age dosage and pimecrolimus 1% for 11 months. Conclusion . It is crucial to perform differential diagnosis with cutaneous mastocytosis in infants with signs of allergic disease and low-positive dynamics of skin process during therapy.