Hypokalemic Periodic Paralysis: Narrative Review
Abstract
Hypokalemic periodic paralysis is a rare genetic pathology characterized by spontaneous muscle weakness up to paralysis along with hypokalemia. The disease development is associated with changes in the CACNA1S, SCN4A, KCNJ2, and KCNJ18 genes regulating ion channels functioning in skeletal muscle cells. This article discusses features of etiology, clinical signs, and treatment methods for hypokalemic periodic paralysis, as well as issues of differential diagnosis with other types of periodic paralysis. Variants of prevention of muscle weakness episodes to improve patients’ quality of life are also covered.
Fields of Study & Subjects
Ion channel regulation and function
Potassium and Related Disorders
Cardiac electrophysiology and arrhythmias
Publication details
- Journal / source
- Вопросы современной педиатрии
- Volume
- 25
- Issue
- 1
- Pages
- 11–16
- Publication date
- 5 February 2026
- Language
- RU