Epigallocatechin gallate increases fatty acid oxidation but not 24-hour survival in lipopolysaccharide-induced endotoxic shock in mice
Abstract
Purpose: This study aimed to explore the effects of epigallocatechin gallate (EGCG) in critically ill patients using a mouse model.Methods: C57BL/6 mice were divided into control and EGCG groups (n=8 per group). The EGCG group received a 0.1% EGCG solution for 2 weeks, after which the mice were intraperitoneally injected with a lethal dose of lipopolysaccharide to induce acute endotoxic shock. Indirect calorimetry was performed for 24 hours. Changes in body weight, epididymal fat weight, and survival were measured, together with serum lipid levels, interleukin-6 (IL-6), and superoxide dismutase (SOD) concentrations. The expression of peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) was determined using quantitative real-time polymerase chain reaction, and its serum concentration was subsequently measured.Results: Indirect calorimetry showed a significant increase in fatty acid oxidation (P
Fields of Study & Subjects
Tea Polyphenols and Effects
Coconut Research and Applications
Ginger and Zingiberaceae research
Publication details
- Journal / source
- 한국정맥경장영양학회지
- Publisher
- Korean Society for Parenteral and Enteral Nutrition/The Korean Society of Surgical Metabolism and Nutrition
- Volume
- 18
- Issue
- 1
- Pages
- 27–33
- Publication date
- 30 March 2026
- Language
- EN