Hybrid hemodynamic modeling for optimization of mechanical circulatory support systems

Objective: to propose and justify approaches for improving the classical hemodynamic test bench, widely used to model the integration of mechanical circulatory support (MCS) systems. Materials and methods . The hemodynamic test bench consisted of multiple containers and resistors simulating systemic and pulmonary circulation, enabling the study of physiological conditions in heart failure (HF). The setup also included an auxiliary circulatory support pump and a pulsatile flow generator. Results. A mathematical model of the cardiovascular system was developed, capable of reproducing physiological states under conditions of pump-assisted circulation and pulsatile flow. Comparative evaluation of experimental and modeling results highlighted the advantages and limitations of different modeling methods. Conclusion. Based on these findings, strategies for further development of the hemodynamic test bench, aimed at enhancing its ability to simulate the impact of mechanical circulatory support on key hemodynamic parameters, were formulated and justified.